I give a quick scrub with a piece of 4x2 lightly dipped in E45 skin cream every 4 shots or so in my Charles Moore .44 pistol. I can feel a ring of crud about three inches up from the chamber which can make getting the next ball seated difficult without hammering. After the scrub the balls seats nicely with hand pressure. I try not to get it too wet so as not to dampen the powder.