I used to be obsessed about crossover, and posted some absolute rubbish on here.
The only common occurrence is if you knock the barrel of an S400, for example, and you try and correct the POI with the scope. Cant is the real enemy..! As said, it can be easily corrected with a good spirit level on the dovetail, and a plumb line. Any scope benefits from being set up at optical zero, as it is then operating with minimum error due to chromatic and spherical abberations, white out, etc. I always use adjustable mounts. An adjustable cheek piece and scope maximiser keeps your eye in the same place, reducing parallax error.
Gus
The ox is slow, but the earth is patient.