Theres not a huge difference in terms of trajectory, between .223 40grvmax , .243 58gr max and .22-250 40gr vmax.
.243 is slightly flatter using 58gr vmax to 400yds than the .22-250 with 40gr vmax, half inch difference. The .223 is virtually the same out to 300yds using 40gr max, then at 400 drops 3" more in comparison to the others. As a rough example.

Personally I would go for the .243 its has equal laser like shooting to a .22-250 and is deer legal for all species in the UK.

I used a .243 for a long time and was tempted by a .223 for foxing with night vision, so i can see the animal drop in the sight due to the softer recoil of the .223.

If using fast bullets the difference is next to nothing out to 300yds, same goes as a comparison with .204 and .223 if using light 40gr heads..its a nats nob difference..