In my case here i am talking about shooting foxes at night with n/v so cannot dial in, and 80% of the time it has to be taken off shooting sticks.
I was thinking on the lines than a 22-250 zeroed at 250-260 yds with the n/v being 2.6" above the bore that i would have a point blank range of around 280-290 yds using 50/53g bullets doing 3,800 fps ?.

Ive done over 500 foxes since ive owned the 223, bullet wise what iv'e found is ballistic tips of 50g-55g have stopped foxes a lot better than 40g bullets, iv'e tried Federal 40g bt's and Hornady 40g bt's and there was clearly a higher percentage of runners with both of these's, ( with good shot placement), got to say that the Hornady 53g v-max home loads seem to be "amongst" the best so far.

Dave (warbucks)