I have no experience of the 50mm version as I generally am not a fan of huge objectives, preferring my sporters to retain sleek lines.
I'd have guessed that performance / durability etc will be the same, but if fitting the larger scope necessitates taller mounts, this could lead to comb / eye alignment issues (obviously dependant on your rifle / stock / comb configuration).
Generally a higher mounted scope will lead to more holdover required at shorter ranges (up to closest zero) but less at longer ranges (beyond primary zero) so much depends on intended use.