It's because BP is an explosive compound, and the air contained in the space would enable an 'explosive front' to generate, causing, mostly, massive damage in a confined space such as bulging of a chamber, or bulging/ringing of an barrel - or at it worst, a burst barrel.
By contrast, nitro propellant compounds do not detonate, but burn, albeit quickly, as far as WE are concerned, but slowly as far a actual physics are concerned.