I have a Pietta Remington.44. I use 18 grains of powder and 18 grains of semolina and a lubed ball. Patches have never figured in my load tests for it. Using this combination the ball seats just nicely in the chamber. Of course the Pedersoli may have different volume chambers. For my pistol 18 grains of the black stuff is where I get the best trade off between accuracy and frugality!