Quickload will give you pressure values you require and it’s up to you to decide to take heed.
Flattened primers occur in factory bought ammo so not always a good indicator to back off,
Check other signs too like hard extraction and ejector / bolt marks on base of case .
It’s great to have as a guide and can be quite accurate if you put all the values in .
Like Amir says 43 gns of abc powder 10 years ago might be 40 gns from today’s abc powder that’s why you should always check current data etc