Hi,
I used to use 46gn of VIT N133 powder with 405gn cast Tim Hannam bullets, but found it punishing on the shoulder, then I was introduced to Reloader 7 42gn with same bullet and found softer kick and more accurate. I use the rounds in my Sharps Pedersoli rolling block rifle and have been using it since.
I hope this is useful to you.
Ajay