Surely if the spring is the same for both calibres (and as far as I know it is for out of the box guns), the cocking effort is the same for both ... except that I can see that if .177 needs more preload then there will be a small increase in effort needed. Personally I have never noticed a difference in cocking effort but agree that in general a .22 can be 'more comfortable' to shoot cf .177.

.177 pellets are usually cheaper than .22
Trajectory is flatter so it could be argued that .177 is the easier to shoot as range estimation is more critical for .22. Not sure this is valid though as I know some exceedingly good .22 shooters (they are also good .177 as well) so I guess it all comes down to knowing your kit and your ranges.
Fur & feather: limited experience tells me there is no difference. Both do the job if pellet is placed correctly.Others may disagree.

Just thoughts,
Cheers, Phil