It's like having and shooting a REAL gun from the good old days.
Get extra cylinders if you can. I use Cheddite primers and Herco. Get a set of phials to transport your pre-measured powder, as many as possible (I've got about 50) or there is a chap on eeebay that sells a plastic device that loads all 6 cylinders at once. I use 148grn HBWC bullets or 140grn 'Cowboy' flat base with around 3.3 grns of the Herco atm but I will be experimenting a bit more with lighter and heavier charge when I get the time. Get a good accurate scale preferably with 'grains' as well as 'grams'.
You will probably experience cylinder jam if you try to shoot much double action due to either badly seated primers or blow back causing primers to jump back. It can be alleviated somewhat by selecting and separating your loose or tight primers and seeing which ones are best for you. In single action it's not so much of a problem. Plenty of info on web btw.
Enjoy, I do.