Please go right ahead and try it out for us.
We are eager to see your results.
BTW, loading 85gr AND grease cookies in a .577-450 doesn't actually leave ANY airspace, in my experience, at least. YMMD.
20% air gap? Might be OK. But basically the practice of leaving a LARGE airspace between a bullet/ball and load WILL result in damage to a BP firearm, ranging from mild ringing to catastrophic failure of the barrel at just about the point where your hand is holding it. Did you even look at the CVA YouTube movie?