Been running on one M4 dog screw for over a hundred shots with no movement or distortion at the dog screw or barrel/block.
Suggests it's durable and a single screw angled towards breech thrust will be more than adequate.
Quite fancy this for instantaneous connection but slot needs tool/skill set a bit above mine methinks. Once 'hooked' into register the breech thrust would keep it there hopefully.
With enough skill more than one dog can be used.