From a purely target shooting perspective....

.22 has a more loopy trajectory than .177 so longer shots are more challenging as you need to be sure of your range and the required hold over. I will confidently go for a 40mm FT target at 55 yards and hit it but if I misrange by only a couple of yards either side its a miss. I've entered and done well in a long range challenge which was a 40mm target at 75yards (8 mildots hold over req'd based on a 20 yard zero) and I recon 100 yards is probably workable in still conditions. Modern airguns are generally inherently very accurate its down to hard work at the practise range to take full advantage of this accuracy.