I had a Python 63 and still have a Pietta Colt Navy in .22 TAC.
Neither is anywhere near as accurate as a decent conventional air pistol, or my EB20 CO2 pistol.
A couple of thou cylinder misalignment might not matter much in .38 or .44 calibre, but it certainly does in .22.
They could have made a much better job without much extra cost.
Regards,
MikB
...history... is, indeed, little more than the register of the crimes, follies, and misfortunes of mankind. (Edward Gibbon: Decline and Fall of the Roman Empire)