It is if you don't do regular maintenance. It's called shooting loose, and happens to ALL the screws on a revolver. The frame screws are Nyloc-type, but since I bought the last four from Ruger about eight years ago, you'll have to find your own if you lose one or it wears out. There are only a certain number of times that they can be tightened up, lessen you use something like Lok-tite blue.
I guess that you mean grip, rather than handle?