Back in pistol days I used to load 11.0 of Unique behind 240 grain bullets, whether JHP or gaschecked Keith type, in my old Ruger Blackhawk. It wasn't the severest load I used, but it was sharp enough not to want heavier if you were firing a few cylinders of 'em. It'd throw bowling pins hard against the backstop, and few of them would survive more than 3 hits or so. Anything more tended to work the action screws loose, even after loctiting them...
I really liked Unique. It worked for me in everything from .32 ACP to .577 Snider.
...history... is, indeed, little more than the register of the crimes, follies, and misfortunes of mankind. (Edward Gibbon: Decline and Fall of the Roman Empire)